In general containment in a dedusting process means, to ensure that no harmful emissions, potent compounds and combustible dust gets out of the process, become airborne and enters the ambient air.
There are two key concerns which are critical when handling pharmaceutical dusts: the potent, toxic or allergenic properties of the compound as it relates to personnel exposure and the explosion properties of the compound.
The first issue involves understanding the toxicological properties of the handled materials, reviewing the occupational exposure limit (OEL) and performing a risk-based exposure evaluation to determine the methods for proper control. Secondly, the fugitive dust particles, which are often invisible to the eye, can create fire and explosion hazards when depositing on the machinery and other surfaces in the production.